b99548fc6477e8f2b46f571248147aab27d5766b
lrnassar
  Tue Jun 30 17:57:20 2026 -0700
Add popEVE proteome-wide missense deleteriousness track for hg38. refs #37791

New heatmap bigBed track under the Deleteriousness Predictions superTrack, built from
the UKBB-trained popEVE v1.1 GRCh38 VCF. One heatmap entry per protein (columns = amino
acid positions at codon coordinates, rows = 20 amino acids), colored on a global,
cross-gene gradient keyed to the raw popEVE score.

Adds the conversion scripts (extractPopEve.py, vcfToPopEveHeatmap.py, popEve_heatmap.as),
the makedoc, the trackDb stanza and description page, and gates the track alpha via an
include in predictionScoresSuper.ra.

diff --git src/hg/makeDb/trackDb/human/popEve.ra src/hg/makeDb/trackDb/human/popEve.ra
new file mode 100644
index 00000000000..577f5cd1ac1
--- /dev/null
+++ src/hg/makeDb/trackDb/human/popEve.ra
@@ -0,0 +1,13 @@
+track popEve
+shortLabel popEVE Scores
+longLabel popEVE proteome-wide missense deleteriousness scores
+type bigBed 12 +
+parent predictionScoresSuper
+bigDataUrl /gbdb/$D/popEve/popEve.bb
+style heatmap
+dataVersion popEVE v1.1 (UKBB), 2025-07-15
+visibility pack
+maxWindowCoverage 200000
+filterText.name .*
+filterType.name regexp
+filterLabel.name Gene symbol