2740c034d0cb877c9bd055c5a897fa458d458bfa
gperez2
  Wed Aug 26 20:38:59 2026 -0700
Defining the MPC acronym per Bob's feedback, and pluralizing "track" to "tracks", in the gnomAD v4.1.1 announcement. refs #38166

diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html
index 2cdc1c06f7d..12ca13960bd 100644
--- src/hg/htdocs/goldenPath/newsarch.html
+++ src/hg/htdocs/goldenPath/newsarch.html
@@ -57,32 +57,32 @@
 found <a target=_blank href="https://genecats.gi.ucsc.edu/builds/versions.html">here</a>. 
 For the full list of our daily code changes head to our <a
 href="https://github.com/ucscGenomeBrowser/kent/commits/master"
 target=_blank>GitHub page</a>. Lastly, see our <a href="credits.html" target="_blank">
 credits page</a> for acknowledgments of the data we host.</p>
 
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 <h2>Aug. 26, 2026 &nbsp;&nbsp; gnomAD v4.1.1 and MPC tracks for hg38</h2>
 <p>
 We are excited to announce the updated
 <b>Genome Aggregation Database (gnomAD) v4.1.1 tracks</b> for human assembly
-hg38/GRCh38, along with a
-new <b>gnomAD MPC track</b>, both found in the <a target=_blank href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadVariants">gnomAD superTrack</a>. The tracks are:</p>
+hg38/GRCh38, and
+new <b>gnomAD Missense Deleteriousness Prediction by Constraint (MPC)</b> tracks, found in the <a target=_blank href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadVariants">gnomAD superTrack</a>. The tracks are:</p>
 <ul>
   <li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadVariantsV4.1" target="_blank">gnomAD v4.1.1</a></b>
   (composite track): Shows exome and genome variants. This release revises the LOFTEE END_TRUNC
   GERP distance threshold from -58.0 to 0.0, reclassifying about 79,920 predicted loss-of-function
   variants from high-confidence to low-confidence.</li>
   <li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadPLI" target="_blank">gnomAD Constraint Metrics</a></b>
   (composite track): The v4.1.1 constraint metrics were recomputed
   using a Bayesian framework instead of the previous frequentist approach, expanded the coverage model
   from a depth cutoff to allele number, and now include chrX and chrY. gnomAD's recommended LOEUF
   threshold changed from &lt;0.35 to &lt;0.45 accordingly. The two v4.1.1 subtracks:
    <ul>
     <li><b>Transcript LoF v4.1.1</b>: gnomAD Predicted Loss of Function Constraint Metrics By Transcript (LOEUF and pLI)</li>
     <li><b>Transcript Missense v4.1.1</b>: gnomAD Predicted Missense Constraint Metrics By Transcript (Z-scores)</li>
    </ul>
   </li>