9227df124b0a433a7b05eb5367ba33589998dcc0 gperez2 Wed Aug 26 20:18:16 2026 -0700 Fixing a misspelled name in the gnomAD v4.1.1 announcement credits: Caitlin Samocha to Kaitlin Samocha. refs #38166 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 48d9d8f085b..2cdc1c06f7d 100644 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -98,31 +98,31 @@ <div class="text-center" style="margin-top: 1.5em;"> <a href="https://genome.ucsc.edu/s/gperez2/gnomADv4.1.1" target="_blank"> <img alt="Genome Browser screenshot of the gnomAD v4.1.1 and MPC tracks" src="/images/newsArchImages/gnomadV4.1.1_MPC.png" width='75%'></a> <p class="gbsCaption"><em>gnomAD v4.1.1 exomes and genomes variants, the LoF and missense constraint tracks, and the four gnomAD MPC allele tracks plus MPC overlaps, at the KCNH1 locus on hg38.</em></p> </div> <p> For more information about the v4.1.1 update, see the <a href="https://gnomad.broadinstitute.org/news/2026-03-gnomad-v4-1-1/" target="_blank">gnomAD blog post</a>.</p> <p> We would like to thank the <a href="https://gnomad.broadinstitute.org/about" target="_blank">Genome -Aggregation Database Consortium</a> for making these data available, and Caitlin Samocha for +Aggregation Database Consortium</a> for making these data available, and Kaitlin Samocha for providing the MPC score data. We would also like to thank Christopher Lee, Maximilian Haeussler, and Gerardo Perez for their efforts on this release.</p> <a name="081126"></a> <h2>Aug. 11, 2026 Deleteriousness Predictions: ClinPred for hg19 and hg38</h2> <p> We are pleased to announce the release of the ClinPred pathogenicity score track for <a href="/cgi-bin/hgTrackUi?db=hg19&g=clinPred&position=default" target="_blank">hg19</a> and <a href="/cgi-bin/hgTrackUi?db=hg38&g=clinPred&position=default" target="_blank">hg38</a>. ClinPred is a machine-learning predictor of pathogenicity for nonsynonymous (missense) single-nucleotide variants, combining existing pathogenicity scores with population allele frequency from gnomAD. It was trained on confidently annotated disease-causing and benign variants from ClinVar. Pre-computed scores are provided for all possible human missense variants in the exome. </p>