+gnomAD v4.1.1 exomes and genomes variants, the LoF and missense +constraint tracks, and the four gnomAD MPC allele tracks plus MPC overlaps, at the KCNH1 locus +on hg38.
+You can sign-up to get these announcements via our Genome-announce email list. We send around one short announcement email every two weeks.
Smaller software changes are not announced here. A summary of the three-weekly release changes can be found here. For the full list of our daily code changes head to our GitHub page. Lastly, see our credits page for acknowledgments of the data we host.
+ ++We are excited to announce the updated +Genome Aggregation Database (gnomAD) v4.1.1 tracks for human assembly +hg38/GRCh38, along with a +new gnomAD MPC track, both found in the gnomAD superTrack. The tracks are:
+
+gnomAD v4.1.1 exomes and genomes variants, the LoF and missense +constraint tracks, and the four gnomAD MPC allele tracks plus MPC overlaps, at the KCNH1 locus +on hg38.
++For more information about the v4.1.1 update, see the gnomAD +blog post.
+ ++We would like to thank the Genome +Aggregation Database Consortium for making these data available, and Caitlin Samocha for +providing the MPC score data. We would also like to thank Christopher Lee, Maximilian Haeussler, +and Gerardo Perez for their efforts on this release.
+We are pleased to announce the release of the ClinPred pathogenicity score track for hg19 and hg38. ClinPred is a machine-learning predictor of pathogenicity for nonsynonymous (missense) single-nucleotide variants, combining existing pathogenicity scores with population allele frequency from gnomAD. It was trained on confidently annotated disease-causing and benign variants from ClinVar. Pre-computed scores are provided for all possible human missense variants in the exome.
Scores range from 0 to 1, with higher values indicating a greater predicted likelihood