de609b7489963f32ad474619cb3dff0283ef7e76 braney Sun Aug 23 15:13:46 2026 -0700 vcf: bound the genotype allele index by the field it is stored in, refs #38155 parseAlleleIx checked the index against alleleCount only. A record can hold up to VCF_MAX_INFO alleles, so an index of 128 or more could pass that check and then narrow on the way into the signed char field. The narrowed value was sometimes another real allele of the record: with 260 ALT alleles, index 260 came out as 4. The parser then reported a genotype the VCF never named. The check now also rejects an index above SCHAR_MAX, so an index too large for the field reads as missing data. SCHAR_MAX and not CHAR_MAX, because CHAR_MAX is 255 on the unsigned char platforms that the field is declared signed for. Every other assignment to hapIxA and hapIxB in this file is a literal in the range -1 to 2, so parseAlleleIx was the only path that could carry an out-of-range value. New test vcfParseManyAlleles, with a record of 260 ALT alleles. Without the fix, GT 128/1 reads as -128/1, 130/130 as -126/-126, and 260/260 as 4/4. diff --git src/lib/tests/makefile src/lib/tests/makefile index 879bd33e16c..78760d99568 100644 --- src/lib/tests/makefile +++ src/lib/tests/makefile @@ -303,31 +303,31 @@ diff expected/$@.out output/$@.out tabixFetch1kGWithGenotypes: ${tabixTester} mkdirs ${tabixTester} input/YRI.low_coverage.2010_07_excerpt.genotypes.vcf.gz 2:26793738-26794385 > output/$@.out diff expected/$@.out output/$@.out ${BIN_DIR}/tabixFetch: tabixFetch.o ${MYLIBS} ${MKDIR} ${BIN_DIR} ${CC} ${COPT} -o ${BIN_DIR}/tabixFetch tabixFetch.o ${MYLIBS} ${L} # vcf: vcfTester=${BIN_DIR}/vcfParseTest vcfTest: vcfParse1kGNoGenotypes vcfParse1kGWithGenotypes vcfParseOldV3 \ vcfHeader1kGNoGenotypes vcfHeader1kGWithGenotypes vcfHeaderOldV3 \ - vcfParseBadGenotypeIx + vcfParseBadGenotypeIx vcfParseManyAlleles vcfParse1kGNoGenotypes: ${vcfTester} mkdirs ${vcfTester} input/YRI.trio.2010_06.novelsequences.sites.vcf.gz 2 26790859 194631353 > output/$@.out diff expected/$@.out output/$@.out vcfParse1kGWithGenotypes: ${vcfTester} mkdirs ${vcfTester} input/YRI.low_coverage.2010_07_excerpt.genotypes.vcf.gz 2 26793737 26794385 > output/$@.out diff expected/$@.out output/$@.out vcfParseOldV3: ${vcfTester} mkdirs ${vcfTester} input/20091110_pilot1_vcf_merged_call_sets_YRI.2and3_way.vcf.gz 1 3000 50000 >& output/$@.out diff expected/$@.out output/$@.out # Regression tests for the tabix header-read path (htslib >= 1.21 tbx_readrec # strips meta_char lines, so the VCF header must be read off the htsFile @@ -339,30 +339,38 @@ vcfHeader1kGWithGenotypes: ${vcfTester} mkdirs ${vcfTester} -headerOnly input/YRI.low_coverage.2010_07_excerpt.genotypes.vcf.gz > output/$@.out diff expected/$@.out output/$@.out vcfHeaderOldV3: ${vcfTester} mkdirs ${vcfTester} -headerOnly input/20091110_pilot1_vcf_merged_call_sets_YRI.2and3_way.vcf.gz > output/$@.out diff expected/$@.out output/$@.out # A GT allele index that this record has no allele for must parse as missing data, so that # every caller sees either a real allele or missing data. vcfParseBadGenotypeIx: ${vcfTester} mkdirs ${vcfTester} -genotypes input/badGenotypeIx.vcf.gz chr1 0 10000 > output/$@.out diff expected/$@.out output/$@.out +# A record can have more alleles than fit in the signed char that holds a genotype's allele +# index. An index too large for the field must also parse as missing data, instead of being +# silently narrowed to some other value. input/manyAlleles.vcf.gz has 260 ALT alleles, so +# index 128 would narrow to a negative value and index 260 to 4, a real allele of that record. +vcfParseManyAlleles: ${vcfTester} mkdirs + ${vcfTester} -genotypes input/manyAlleles.vcf.gz chr1 0 10000 > output/$@.out + diff expected/$@.out output/$@.out + ${BIN_DIR}/vcfParseTest: vcfParseTest.o ${MYLIBS} ${MKDIR} ${BIN_DIR} ${CC} ${COPT} -o ${BIN_DIR}/vcfParseTest vcfParseTest.o ${MYLIBS} ${L} # hacTree: hacTreeTester=${BIN_DIR}/hacTreeTest hacTreeTest: ${hacTreeTester} mkdirs ${hacTreeTester} input/$@.txt output/$@.out diff expected/$@.out output/$@.out ${BIN_DIR}/hacTreeTest: hacTreeTest.o ${MYLIBS} ${MKDIR} ${BIN_DIR} ${CC} ${COPT} -o ${BIN_DIR}/hacTreeTest hacTreeTest.o ${MYLIBS} ${L}