8296c9b7908b7fd73c70b6c7af21c337c55558f4 lrnassar Mon Sep 21 04:39:42 2026 -0700 Wording and formatting fixes to the mouseStrainsCactus description page and the AVI news entry, per CR feedback. refs #38351 mouseStrainsCactus.html: use the standard "Display Conventions and Configuration" heading, spell misassemblies without the hyphen, hyphenate large-scale, add the missing commas before "and" in two sentences, finish the Data Access sentence about the API track name, and put the references in alphabetical order by first author. newsarch.html: correct the track group name to "Phenotypes, Variants, and Literature", hyphenate genome-wide, and add the missing "on" in the figure caption. diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 8fe053fbf81..7c0a1336af5 100644 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -72,44 +72,44 @@ (AVI) score</a> from Google DeepMind's AlphaGenome Atlas, on the human GRCh38/hg38 assembly. The score combines AlphaGenome's predictions of how a variant affects gene regulation, covering expression, splicing, chromatin accessibility and transcription factor binding across hundreds of cell types, with AlphaMissense predictions for protein-altering changes. The result is a single number that ranks how damaging a substitution is likely to be. Unlike most prediction scores, it covers non-coding variants as well as coding ones, across the whole genome. </p> <div class="text-center" style="margin-top: 1.5em;"> <a href="https://genome.ucsc.edu/s/Lou/AlphaGenome" target="_blank"> <img alt="AlphaGenome AVI scores across the TERT locus, showing four per-allele subtracks with elevated scores over the gene's 5' end and its highlighted promoter" src="/images/newsArchImages/alphaGenome.png" width='65%'></a> <p class="gbsCaption"><em>AVI scores at the TERT locus on hg38, one subtrack per alternate allele. Scores stay high across the highlighted promoter, shown in red as EH38E3622530, and fall -to background either side. The two promoter mutations most often seen in cancer sit inside it, +to background on either side. The two promoter mutations most often seen in cancer sit inside it, beyond the end of every TERT transcript.</em></p> </div> <p> The track shows the precomputed score for every possible single-base substitution, about 8.8 billion in all, with one subtrack per alternate allele. Scores are PHRED-scaled, so 10 marks the -top 10 percent of substitutions genome wide, 20 the top 1 percent and 30 the top 0.1 percent. +top 10 percent of substitutions genome-wide, 20 the top 1 percent and 30 the top 0.1 percent. Hover the mouse over any position to see the score, and zoom in to see individual bases. </p> <p> -The AlphaGenome Variant Impact (AVI) score track can be found in the "Phenotype and Literature" -group, inside the +The AlphaGenome Variant Impact (AVI) score track can be found in the +"Phenotypes, Variants, and Literature" group, inside the <a href="/cgi-bin/hgTrackUi?db=hg38&g=predictionScoresSuper&position=default" target="_blank">Deleteriousness Predictions</a> track collection, so it can be compared with other prediction scores such as <a href="/cgi-bin/hgTrackUi?db=hg38&g=caddSuper1_7&position=default" target="_blank">CADD</a>, <a href="/cgi-bin/hgTrackUi?db=hg38&g=revel&position=default" target="_blank">REVEL</a>, <a href="/cgi-bin/hgTrackUi?db=hg38&g=eve&position=default" target="_blank">EVE</a>, <a href="/cgi-bin/hgTrackUi?db=hg38&g=primateAi&position=default" target="_blank">PrimateAI</a> and <a href="/cgi-bin/hgTrackUi?db=hg38&g=promoterAi&position=default" target="_blank">PromoterAI</a>. AlphaGenome has not been validated for, and is not approved for, any clinical use. </p> <p> We thank Google DeepMind for making the data available. See the <a href="/cgi-bin/hgTrackUi?db=hg38&g=alphaGenome&position=default" target="_blank">track description page</a> for details on the data, methods and licensing. The AVI data cannot be redistributed by UCSC, so it