1db5c89d97fdd3c3580c4ba9b18eba6b5029c97d
max
  Thu Sep 17 05:09:56 2026 -0700
hgSearch: highlight MANE transcript(s) in RefSeq protein-position search results, refs #38285

#Preview2 week - bugs introduced now will need a build patch to fix
A gene-symbol + codon-range search (e.g. "BRCA1 100-200") maps to every
RefSeq isoform prediction sharing that genomic footprint, which can be
dozens of near-identical NP_ accessions with no indication of which one
is the clinically-relevant MANE transcript. Cross-reference the mane
bigGenePred track by genomic overlap + protein accession and call out
the MANE Select/Plus Clinical transcript(s) in their own section above
the rest, gated behind showManeInSearch (default off) in hg.conf.

diff --git src/hg/htdocs/inc/hgSearch.html src/hg/htdocs/inc/hgSearch.html
index 2324562c98f..ed917b9c7d8 100644
--- src/hg/htdocs/inc/hgSearch.html
+++ src/hg/htdocs/inc/hgSearch.html
@@ -26,30 +26,36 @@
 
 .jstree-anchor {
     height: auto !important;
     white-space: normal !important;
 }
 
 .liNoStyle {
     list-style-type: none;
     font-size: larger;
 }
 
 .searchResult {
     font-size: 14px;
 }
 
+.maneSectionHeader {
+    font-weight: bold;
+    font-size: 14px;
+    margin-top: 5px;
+}
+
 .showMoreDiv {
     display: inline;
 }
 
 .headerSpacer {
     padding-top: 15px;
 }
 
 .rowSpacer {
     padding-top: 5px;
 }
 
 .ulNoStyle {
     padding-left: 0;
 }