1259dcfba3a263d92d2602665fd866dc44b47996 lrnassar Sun Jun 21 11:17:10 2026 -0700 Clarify varFreqs description page wording per code review feedback. refs #37733 Reword the default_an sentence in the Pooled allele frequency sections of varFreqsAffected.html and varFreqsBackground.html to explain that cohorts publishing only AF are pooled via an assigned default_an, with per-arm AC derived as round(AF * default_an). Change "tokens" to "terms" in the Consequence filter section of varFreqs.html. diff --git src/hg/makeDb/trackDb/human/varFreqs.html src/hg/makeDb/trackDb/human/varFreqs.html index 44840eb1a7c..fb6fc359c6c 100644 --- src/hg/makeDb/trackDb/human/varFreqs.html +++ src/hg/makeDb/trackDb/human/varFreqs.html @@ -52,31 +52,31 @@

On the Disease and Population reference tracks, Affected AF and Background AF are pooled across contributing cohort arms (sum of allele counts divided by sum of allele numbers), not the maximum across arms, so the displayed frequency matches the carrier-count scale and a small cohort with a high local frequency does not dominate the value. See the "Pooled allele frequency" section on each combined track's description page for which cohorts contribute to the pool numerator and denominator.

Consequence filter — the "Other" bucket

All three combined tracks share the same Consequence filter (Missense, Synonymous, Stop Gained, Frameshift, Splice Donor, Splice Acceptor, Intron, 3' UTR, 5' UTR, Non-coding, -Intergenic, Other). The filter uses OR logic across the comma-separated consequence tokens +Intergenic, Other). The filter uses OR logic across the comma-separated consequence terms on each variant: a variant tagged stop_gained,frameshift is selected by either the "Stop Gained" or the "Frameshift" filter. The "Other" bucket catches the less common Sequence Ontology consequence that don't fit the named buckets above. Examples include splice_region (variant near a splice site but outside the canonical donor/acceptor), start_lost / stop_lost (variant disrupts the start codon or replaces the stop codon with a coding amino acid), stop_retained (variant changes the stop codon but keeps it a stop), inframe_insertion / inframe_deletion (in-frame indel that adds or removes whole codons), and coding_sequence (CDS variant where the precise impact is undetermined). If you include "Other" in the filter selection, no records will be hidden by the consequence filter.