030cc7d4165ee6b37bd4c9ecfb443fb39ac2468d
max
  Mon Nov 3 07:59:26 2025 -0800
updating mexico biobank track, and related tracks, refs #36259

diff --git src/hg/makeDb/trackDb/human/hg38/varFreqs.html src/hg/makeDb/trackDb/human/varFreqs.html
similarity index 84%
rename from src/hg/makeDb/trackDb/human/hg38/varFreqs.html
rename to src/hg/makeDb/trackDb/human/varFreqs.html
index 7f0f1473060..b68cab22aa6 100644
--- src/hg/makeDb/trackDb/human/hg38/varFreqs.html
+++ src/hg/makeDb/trackDb/human/varFreqs.html
@@ -1,30 +1,36 @@
 <h2>Description</h2>
 <p>
 This container track contains annotation tracks with variant frequencies, aka
 allele frequencies, from these projects:
 </p>
 
 <ul>
     <li>
       <b>Mexico Biobank (MXB)</b>: This track displays alleles and their haplotype linkage from the Mexico Biobank
       (MXB), based on genotyping of 6,011 individuals sampled across all 32 states of Mexico during
       the 2000 National Health Survey (ENSA 2000) conducted by the National Institute of Public Health (INSP).
     </li>
     <li>
       <b>Mexico City Prospective Study (MCPS)</b>: This track displays only the allele frequencies from the Mexico City
-      Prospective Study (MXB). From 9,950 whole genome sequenced individuals and 141,046 exome sequenced and genotyped individuals from the Mexico City Prospective Study (MCPS). For details see Ziyatdinov A, Nature 2023 in the reference section of this page. Data version from January 2023.
+      Prospective Study (MXB). From 9,950 whole genome sequenced individuals and 141,046 exome sequenced and genotyped individuals from the Mexico City Prospective Study (MCPS). For details see Ziyatdinov A, Nature 2023 in the reference section of this page.
+    </li>
+    <li>
+      <b>Million Exomes Project (ME)</b>: Variant frequencies from whole-exome sequencing data from 983,578 individuals sequenced by the Regeneron Genetics Center (RGC). These data span dozens of collaborations including large biobanks and health systems. All data were generated by the RGC on a single, harmonized sequencing and informatics protocol. The dataset includes individuals across diverse ancestral populations, encompassing outbred and founder populations and cohorts with high rates of consanguinity. 
+    </li>
+    <li>
+      <b>NHLBI TOPMED Freeze 8</b>: NHLBI TOPMed (Trans-Omics for Precision Medicine) program, launched by the U.S. National Heart, Lung, and Blood Institute, integrates whole-genome sequencing with molecular, clinical, and environmental data from large, well-phenotyped cohorts. Its goal is to uncover the biological mechanisms underlying heart, lung, blood, and sleep disorders to advance precision medicine and improve population health. Freeze 10 contains 868,581,653 variants from 150,899 whole genomes
     </li>
 </ul>
 
 <h2>Display Conventions</h2>
 
 <p>
 In "pack" mode, the MXB track sorts the haplotypes. This can be useful for determining the
 similarity between the samples and inferring inheritance at a particular locus.
 For a full description of how the display works, please see our 
 <a href="../goldenpath/help/hgVcfTrackHelp.html">Haplotype Display help page</a>.
 Briefly, each sample's phased and/or homozygous genotypes are split into haplotypes,
 clustered by similarity around a central variant (in pink), and sorted for
 display by their position in the clustering tree. Click a variant to center on it.
 The tree (as space allows) is drawn in the label area next to the track image.
 Leaf clusters, in which all haplotypes are identical (at least for the variants