6a7655f06c1581853f1a028eb29e17caecfba6a0
max
  Wed Oct 29 07:26:54 2025 -0700
adding RNA modifications superTrack, refs #36613

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+<h2>Description</h2>
+<p>
+Like DNA, RNA also can carry chemical modifications. N 6‐methyladenosine (m6A),
+installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the
+most prevalent mRNA modification. m6A methylation regulates gene expression by
+influencing numerous aspects of mRNA metabolism, including pre‐mRNA processing,
+nuclear export, decay, and translation.  </p>
+<p>
+
+<h2>Display Conventions</h2>
+<p>Methylated sites are highlighted.
+</p>
+
+<h2>Data Access</h2>
+<p>
+todo.
+</p>
+
+<h2>Methods</h2>
+<p>
+For the fetal data from Xiao 2019, data was downloaded from NCBI GEO GSE114150 in bed format and merged with a custom Python script.
+</p>
+
+<h2>Credits</h2>
+<p>
+Thanks to Natacha Clairet and Guillaume Riviere for paper suggestions.
+</p>
+
+<h2>References</h2>
+<p>
+Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W <em>et al</em>.
+<a href="https://doi.org/10.1038/s41556-019-0315-4" target="_blank">
+The RNA N(6)-methyladenosine modification landscape of human fetal tissues</a>.
+<em>Nat Cell Biol</em>. 2019 May;21(5):651-661.
+PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/31036937" target="_blank">31036937</a>
+</p>
+