00334da1123c09a4a857339398546e2eaf94de0f brianlee Fri Jun 5 13:06:56 2026 -0700 Marking Broad/ADGC4 items as active=inprogress per PI Sami email June 2026 diff --git src/hg/cirm/gateway/htdocs/sspsygeneTimeline.html src/hg/cirm/gateway/htdocs/sspsygeneTimeline.html index 4fd949e77c7..84f9491f0da 100755 --- src/hg/cirm/gateway/htdocs/sspsygeneTimeline.html +++ src/hg/cirm/gateway/htdocs/sspsygeneTimeline.html @@ -56,38 +56,38 @@ section AIM 1 section AIM 2 Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from Capstone Lines 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_I_8, 2025-03-31, 0d Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH B 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : active, milestone, ADGC1_JK_8, 2025-09-30, 0d Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH C 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_LM_8, 2026-03-31, 0d Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH D 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_NO_8, 2026-09-30, 0d Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH E 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_P_8, 2026-12-31, 0d Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH F 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_Q_8, 2027-03-31, 0d Submit L0-L1 from BATCH B, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_LM_111213, 2026-03-31, 0d Submit L0-L1 from BATCH C, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_NO_111213, 2026-09-30, 0d Submit L0-L1 from BATCH D, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_P_111213, 2026-12-31, 0d %% Submit L0-L1 from BATCH E-G, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_Q_111213, 2027-03-31, 0d Submit Batch F, producing bulk RNA-seq profiles 4 reps/gene x (10 NPD + 2 ctrl) x 1 (KOLF2.2J/CIRM) iPSC background lines; fastq : crit, milestone, ADGC1_Y4_O_13, 2026-09-30, 0d - Submit data from Batch G, producing bulk RNA-seq profiles (4 replicates per gene x (10 NPD iPSC lines + 2 controls) x 1 background (KOLF2.2J/CIRM) iPSC background lines; fastq)) : crit, milestone, ADGC1_Y4_P_13, 2026-12-31, 0d + Submit data from Batch G, producing bulk RNA-seq profiles (4 replicates per gene x (10 NPD iPSC lines + 2 controls) x 1 background (KOLF2.2J/CIRM) iPSC background lines; fastq) : crit, milestone, ADGC1_Y4_P_13, 2026-12-31, 0d Complete villages - submit L0-L1 to DRACC : crit, milestone, ADGC1_JK_14, 2025-09-30, 0d Village Analysis - submit L0-L1 to DRACC : crit, milestone, ADGC1_LM_14, 2026-03-31, 0d Calcium Imaging Capstone Analysis 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_K_15, 2025-09-30, 0d Calcium Imaging analysis excitatory/inhibitory neurons - Capstone Analysis 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_M_15, 2026-03-31, 0d Calcium Imaging Experiments and analysis of future batches 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds (Submit L0-L4 to DRACC) : crit, milestone, ADGC1_NOPQ_15, 2027-03-31, 0d Calcium Imaging excitatory neurons Batch F 2 time points, 4 replicates/gene, 4 NPD + 2 control iPSC lines, 2 backgrounds; TIFF : crit, milestone, ADGC1_Y4_O_15, 2026-09-30, 0d - Calcium Imaging excitatory neurons Batch G 2 time points, 4 replicates/gene, 4 NPD + 2 control iPSC lines, 2 background; TIFF : crit, milestone, ADGC1_Y4_P_15, 2026-12-31, 0d + Calcium Imaging excitatory neurons Batch G 2 time points, 4 replicates/gene, 4 NPD + 2 control iPSC lines, 2 backgrounds; TIFF : crit, milestone, ADGC1_Y4_P_15, 2026-12-31, 0d Perform StimScope ephys on lines with excitatory calcium imaging (Batches B–E); submit all data levels to DRACC : crit, milestone, ADGC1_Y4_O_16, 2026-09-30, 0d section AIM 3 Perform codex Capstone Lines (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_J_161718, 2025-06-30, 0d Spatial Proteomics Analysis Capstone Lines : crit, milestone, ADGC1_K_161718, 2025-09-30, 0d Perform codex BATCH B (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_L_161718, 2025-12-31, 0d Spatial Proteomics Analysis BATCH B : crit, milestone, ADGC1_M_161718, 2026-03-31, 0d Perform codex BATCH C (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_N_161718, 2027-03-31, 0d Spatial Proteomics Analysis BATCH C : crit, milestone, ADGC1_O_161718, 2027-03-31, 0d Perform codex and analysis for future batches : crit, milestone, ADGC1_Q_161718, 2027-03-31, 0d Spatial Proteomics Analysis for Batch A-C - Submit L2-L4 Data to DRACC Upon Completion : crit, milestone, ADGC1_Y4_O_19, 2026-09-30, 0d Perform Spatial Proteomics for Batch D-E and transfer all data files to DRACC : crit, milestone, ADGC1_Y4_P_19, 2026-12-31, 0d Organoid snRNAseq analysis for Capstone Genes : crit, milestone, ADGC1_J_1920, 2025-06-30, 0d Perform snRNAseq for BATCH B (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 2-4 organoid replicates/line; tif format) : crit, milestone, ADGC1_K_1920, 2025-09-30, 0d Organoid snRNAseq analysis for BATCH B : crit, milestone, ADGC1_L_1920, 2025-12-31, 0d @@ -230,46 +230,46 @@ <div class="col-md-12"> <pre class="mermaid"> gantt dateFormat YYYY-MM-DD axisFormat %Y-Q%q title ADGC4 Broad [R01MH128366] section Grant Year Start Grant Year 3 :milestone, year3_broad, 2025-03-31, 0d Start Grant Year 4 :milestone, m1, 2026-03-31, 0d Start Grant Year 5 :milestone, m1, 2027-03-31, 0d click year3_broad href "https://docs.google.com/spreadsheets/d/1BwaO6rgn0o5nTulC2M6dQe5UMGUWEy-o/edit?gid=2037309850#gid=2037309850&range=D1:D16" section Aim 1 - Submit 100,000 scRNA-seq profiles per cell type (fastq) of 191 genes in 3 cell types : crit, milestone, ADGC4_Aim1_year4_E_3, 2026-03-31, 0d - Submit image dataset of 120 TB (443 genes in 3 cells 5 million profiles) : crit, milestone, ADGC4_Aim1_year4_E_4, 2026-03-31, 0d + Submit 100,000 scRNA-seq profiles per cell type (fastq) of 191 genes in 3 cell types : active, milestone, ADGC4_Aim1_year4_E_3, 2026-03-31, 0d + Submit image dataset of 120 TB (443 genes in 3 cells 5 million profiles) : active, milestone, ADGC4_Aim1_year4_E_4, 2026-03-31, 0d Submit remaining image datasets : crit, milestone, ADGC4_Aim1_year5_item1, 2027-03-31, 0d section Aim 2 - Submit 100,000 scRNA-seq profiles per cell type of 191 genes in 3 cell types (fastq) : crit, milestone, ADGC4_Aim2_year4_E_9, 2026-03-31, 0d + Submit 100,000 scRNA-seq profiles per cell type of 191 genes in 3 cell types (fastq) : active, milestone, ADGC4_Aim2_year4_E_9, 2026-03-31, 0d Submit 50 TB of calcium imaging and MERFISH data : done, milestone, ADGC4_Aim2_year3_D_11, 2025-03-31, 0d - Submit 5 TB of optical electrophysiology data - DATA QUALITY BEING ASSESSED : crit, milestone, ADGC4_Aim2_year3_D_10, 2026-03-31, 0d - Submit 5 TB of optical electrophysiology data : crit, milestone, ADGC4_Aim2_year4_E_10, 2026-03-31, 0d + Submit 5 TB of optical electrophysiology data - DATA QUALITY BEING ASSESSED : active, milestone, ADGC4_Aim2_year3_D_10, 2026-03-31, 0d + Submit 5 TB of optical electrophysiology data - broken scope : crit, milestone, ADGC4_Aim2_year4_E_10, 2026-03-31, 0d Submit remaining optical electrophysiology data : crit, milestone, ADGC4_Aim2_year5_item1, 2027-03-31, 0d section Aim 3 Submit RNA-seq profiles - ANALYSIS / SUBMISSION UNDERWAY : active, milestone, ADGC4_Aim3_year3_D_15, 2025-03-31, 0d - Submit RNA-seq profiles from >10,000 cells : crit, milestone, ADGC4_Aim3_year4_E_15, 2026-03-31, 0d + Submit village RNA-seq profiles from >10,000 cells : active, milestone, ADGC4_Aim3_year4_E_15, 2026-03-31, 0d Submit remaining RNA-seq profiles : crit, milestone, ADGC4_Aim3_year5_item1, 2027-03-31, 0d - Submit 10 TB of associated images to DRACC : crit, milestone, ADGC4_Aim3_year4_D_16, 2026-03-31, 0d + Submit 10 TB of associated images to DRACC : active, milestone, ADGC4_Aim3_year4_D_16, 2026-03-31, 0d Submit remaining morphology imaging : crit, milestone, ADGC4_Aim3_year5_item2, 2027-03-31, 0d </pre> </div> </div> <a name="ADGC5"></a> <!-- Start of ADGC5 Henry Gantt Chart--> <div class="cirm-page-title back-light-blue"><h5 class="cirm-page-title-text">ADGC5 Scripps/Broad timeline</h5></div> <div class="row"> <div class="col-md-12"> <pre class="mermaid"> gantt dateFormat YYYY-MM-DD axisFormat %Y-Q%q title ADGC5 Scripps/Broad [R01MH137042-01/-02]