-This composite shows TAD boundaries across 21 human samples (7 cell lines and 14 -primary tissues) from Schmitt et al., 2016. A boundary is the insulating region -that separates two adjacent topologically associating domains. These are -boundaries, not domains; for domain intervals see the Dixon 2012 TADs track. -
--Each boundary is a 40 kb bin; the bin width reflects the localization precision of the -40 kb analysis, not a measured physical width. Subtracks are grouped by sample type -(cell line vs. primary tissue) and organ system, and colored by organ system. Because the -same boundary is reported independently per sample, turning on multiple subtracks lets you -read boundary conservation directly: a boundary present in many samples is constitutive, -while one present in few is cell-type specific. By default a representative subset of -samples is shown. -
--Boundaries were called with the insulation-score method at 40 kb resolution (1 Mb -insulation square, 200 kb delta window) as described in Schmitt et al., 2016 -(Supplementary Table S3). Per-sample boundary bins were obtained on assembly hg19; for -this assembly they were used natively or lifted with the UCSC liftOver tool, with a -small fraction of bins that did not map cleanly dropped. -
- --The raw data can be explored interactively with the -Table Browser or the -Data Integrator. For programmatic access, the -track can be accessed using the Genome Browser's -REST API. -The underlying bigBed files can be downloaded from our -download server. -
- --Schmitt AD, Hu M, Jung I, Xu Z, Qiu Y, Tan CL, Li Y, Lin S, Lin Y, Barr CL, Ren B. -A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human -Genome. Cell Rep. 2016;17(8):2042-2059. -doi:10.1016/j.celrep.2016.10.061 -