The mouse-over gives the probe ID, how many episignatures cover the site, and the episignature with the largest effect there with its disorder, direction, and delta-beta.
Clicking a site opens a page with a table of every episignature at that site, one row each, giving the gene or locus, the disorder, its OMIM entry, the direction, the delta-beta, the adjusted p-value, and the multiple-testing correction that the publishing study used. Studies differ in which correction they applied, so the adjusted p-values in one row are not always directly comparable with those in another.
-Three filters are available on the track configuration page. The episignature filter keeps only -sites that are part of all of the selected episignatures, which is the way to find the -CpGs that two or more disorders have in common. The other two keep a site by how many -episignatures cover it and by the direction and size of the strongest change at it. +Four filters are available on the track configuration page. The Episignature filter +keeps only sites that are part of all of the selected episignatures, which is the way +to find the CpGs that two or more disorders have in common. The others keep a site by the +Number of episignatures at this probe, the Direction of methylation change, and the +Absolute delta-beta of the strongest episignature at this probe. The last one also +appears on the Episignatures collection page, where it filters both tracks at once.
The 24 episignatures in the track, with the number of CpG sites each contributes and the study that published it. Two signatures are listed for Kabuki syndrome, from a 2017 and a 2026 study, and they are kept apart rather than merged.
| Episignature | Disorder | OMIM | CpG probes | Reference |
|---|---|---|---|---|
| 16pDel | Autism spectrum | 611913 | 106 | Siu 2019 |
| ANKRD11 | KBG syndrome | 148050 | 82 | Awamleh 2023 |