198c9b8daecc44fbda6a6494c566c723920f030a lrnassar Wed Mar 11 18:25:21 2026 -0700 Fixing a few hundred clear typos with the help of Claude. Some are less important in code comments, but majority of them are in user-facing places. I manually approved 60%+ of the changes and didn't see any that were an incorrect suggestion, at worst it was potentially uncessesary, like a code comment having cant instead of can't. No RM. diff --git src/hg/makeDb/trackDb/human/encodeUncFaire.html src/hg/makeDb/trackDb/human/encodeUncFaire.html index 482520aa6b6..0bd53c81f38 100644 --- src/hg/makeDb/trackDb/human/encodeUncFaire.html +++ src/hg/makeDb/trackDb/human/encodeUncFaire.html @@ -38,31 +38,31 @@ one subtrack, uncheck the box next to the track you wish to hide. For more information about the graphical configuration options, click the Graph configuration help link. Note that the graphical configuration options are available only for the Signal subtrack; the Peaks subtracks are fixed.

Methods

To perform FAIRE, proteins were cross-linked to DNA using 1% formaldehyde solution, the complex was sheared using sonication, and a phenol/chloroform extraction was performed to remove DNA fragments crosslinked to protein. The DNA recovered in the aqueous phase was fluorescently-labeled and hybridized to a microarray along with fluorescently-labeled genomic DNA as a control. Ratios were scaled by subtracting the Tukey Bi-weight mean for the log-ratio values from each -log-ratio value, as recomended by NimbleGen. Results in yeast were +log-ratio value, as recommended by NimbleGen. Results in yeast were consistent with enrichment for nucleosome-depleted regions of the genome. Therefore, the method may have utility as a positive selection for genomic regions with properties normally detected by assays like DNAse hypersensitivity.

Verification

The data were verified using PCR with primers designed to promoters enriched with FAIRE and downstream coding regions.

Credits

Cell culture, fixing, and DNA amplification were performed by Jonghwan Kim in the Vishy Iyer lab at the University of Texas, Austin. FAIRE was done by Paul Giresi in