198c9b8daecc44fbda6a6494c566c723920f030a lrnassar Wed Mar 11 18:25:21 2026 -0700 Fixing a few hundred clear typos with the help of Claude. Some are less important in code comments, but majority of them are in user-facing places. I manually approved 60%+ of the changes and didn't see any that were an incorrect suggestion, at worst it was potentially uncessesary, like a code comment having cant instead of can't. No RM. diff --git src/hg/makeDb/trackDb/human/hg38/encodeCcreCombined.html src/hg/makeDb/trackDb/human/hg38/encodeCcreCombined.html index 37f9f6b8038..e73ae1e93c3 100644 --- src/hg/makeDb/trackDb/human/hg38/encodeCcreCombined.html +++ src/hg/makeDb/trackDb/human/hg38/encodeCcreCombined.html @@ -58,31 +58,31 @@ DNase-H3K4me3 DNase-H3K4me3 blue CTCF CTCF-only CTCF-only

The DNase-H3K4me3 elements are those with promoter-like biochemical signature that are not within 200bp of an annotated TSS.

Methods

-All individual DNase hypsersensitive sites (DHSs) identified from 706 DNase-seq experiments +All individual DNase hypersensitive sites (DHSs) identified from 706 DNase-seq experiments in humans (a total of 93 million sites from 706 experiments) were iteratively clustered and filtered for the highest signal across all experiments, producing representative DHSs (rDHSs), with a total of 2.2 million such sites in human. The highest signal elements from this set that were also supported by high H3K4me3, H3K27ac and/or CTCF ChIP-seq signals were designated cCRE's (a total of 926,535 in human).

Classification of cCRE's was performed based on the following criteria:

  1. cCREs with promoter-like signatures (cCRE-PLS) fall within 200 bp of an annotated GENCODE TSS and have high DNase and H3K4me3 signals.
  2. cCREs with enhancer-like signatures (cCRE-ELS) have high DNase and H3K27ac with low H3K4me3 max-Z score if they are within 200 bp of an annotated TSS. The subset of cCREs-ELS within 2 kb of a TSS is denoted proximal (cCRE-pELS), while the remaining subset is denoted distal (cCRE-dELS).