0656b0a9ad98986ef3944b6ceaf305ab08ca4e39 max Fri Jul 24 01:10:13 2026 -0700 noyvertSv: swap UK Biobank r2 filter for leave-one-out metrics, revise description Per author (Boris Noyvert) request, replace the r2Ukb (UK Biobank imputation r2) filter with r2Loo and concordanceLoo, the primary SV imputation quality measures for the multi-ancestry reference panel (r2Ukb mainly reflects European-ancestry performance). Both fields already exist in noyvert.bb, so this is a trackDb-only change. Also update the description page with the author's revised text, including a comparison with the 1KG ONT Vienna dataset. refs #37888 diff --git src/hg/makeDb/doc/hg38/lrSv.txt src/hg/makeDb/doc/hg38/lrSv.txt index 07a7fe15cc3..df579e947d4 100644 --- src/hg/makeDb/doc/hg38/lrSv.txt +++ src/hg/makeDb/doc/hg38/lrSv.txt @@ -757,15 +757,28 @@ bigBedToBed NIH_CARD_longReadSVs.bb stdout \ | python3 $HOME/kent/src/hg/makeDb/scripts/lrSv/lrSvCardBbToBed.py /dev/stdin cardSv.bed # CARD: 228,855 input records written; by type: DEL=101,570, DUP=1, # INS=126,853, INV=431 bedSort cardSv.bed cardSv.sorted.bed bedToBigBed -type=bed9+ -as=$HOME/kent/src/hg/makeDb/scripts/lrSv/lrSvCard.as \ -tab cardSv.sorted.bed /hive/data/genomes/hg38/chrom.sizes cardSv.bb # Max allele counts: AC=702 (2x351), nabecAc=410 (2x205), hbccAc=292 (2x146). # trackDb filter ranges/labels updated to allele counts; mouseOver and the # cardSv.html / lrSv.html wording changed from "carriers" to "allele counts". # # Re-ran the merge so lrSvAll carries CARD's allele counts (databases.tsv # unchanged; CARD still contributes via valueField=AC): python3 ~/kent/src/hg/makeDb/scripts/lrSv/lrSvMergeAll.py # 3,018,404 input -> 2,582,278 merged, 16 databases (unchanged structure). + +########## +# 2026-07-24 Claude max +# +# noyvertSv: per author (Boris Noyvert) request, replaced the UK Biobank +# imputation-r2 filter (r2Ukb) with two leave-one-out reference-panel quality +# filters, r2Loo and concordanceLoo, which are the primary SV imputation +# quality measures for the multi-ancestry panel (r2Ukb mainly reflects +# European-ancestry performance). trackDb-only change; both fields already +# exist in noyvert.bb (floats, 0:1), so no rebuild was needed. Also replaced +# the Description text on noyvertSv.html with the author's revised version +# (reordered, plus a comparison with the 1KG ONT Vienna dataset, Schloissnig +# et al. 2025).