-Regulatory functional assays are methods that directly test whether specific -DNA sequences control gene expression - such as by acting as enhancers, -promoters, silencers, or other regulatory elements — by measuring their effect -on transcription in cells. Among these, Massively Parallel Reporter Assays -(MPRAs) are high-throughput experimental methods that test thousands of DNA -sequences or genetic variants for their effects on gene -regulation by measuring transcriptional output using sequencing. +Massively Parallel Reporter Assays +(MPRAs) are high-throughput experimental methods that measure +transcriptional output of thousands of short DNA sequences using sequencing. +If in addition, a mutated sequence is tested, the impact of a genetic variant can be quantified.
This track collection brings together results from two MPRA databases, one for the complete sequence fragments, -one for the variants in selected fragments: +one for the impact of variants in selected fragments: