697dc500699e5926a9ba084a264354baefbafb2f max Sun Apr 5 23:20:10 2026 -0700 docs update diff --git src/hg/makeDb/trackDb/human/hg38/mpra.html src/hg/makeDb/trackDb/human/hg38/mpra.html index 940a9f0bb03..2d9d9aefb98 100644 --- src/hg/makeDb/trackDb/human/hg38/mpra.html +++ src/hg/makeDb/trackDb/human/hg38/mpra.html @@ -1,28 +1,25 @@ <h2>Description</h2> <p> -Regulatory functional assays are methods that directly test whether specific -DNA sequences control gene expression - such as by acting as enhancers, -promoters, silencers, or other regulatory elements — by measuring their effect -on transcription in cells. Among these, Massively Parallel Reporter Assays -(MPRAs) are high-throughput experimental methods that test thousands of DNA -sequences or genetic variants for their effects on gene -regulation by measuring transcriptional output using sequencing. +Massively Parallel Reporter Assays +(MPRAs) are high-throughput experimental methods that measure +transcriptional output of thousands of short DNA sequences using sequencing. +If in addition, a mutated sequence is tested, the impact of a genetic variant can be quantified. </p> <p> This track collection brings together results from two MPRA databases, one for the complete sequence fragments, -one for the variants in selected fragments: +one for the impact of variants in selected fragments: </p> <ul> <li><b><a href="hgTrackUi?g=mprabase">MPRA Base</a></b> — 41,275 experimentally tested cis-regulatory elements from 51 MPRA, STARR-seq, and related reporter assay experiments, curated in the MPRA Base database (<a href="https://pubmed.ncbi.nlm.nih.gov/38045264/" target="_blank">Zhao et al., 2023</a>). </li> <li><b><a href="hgTrackUi?g=mpraVarDb">MPRAVarDB</a></b> — 242,818 variants from 18 MPRA studies, tested for effects on transcriptional regulatory activity across over 30 cell lines and 30 human diseases and traits (<a href="https://pubmed.ncbi.nlm.nih.gov/38617248/" target="_blank">Wang et al., 2024</a>). </li> </ul>