31b7d4342181171f8b8271e5ed5b5cdaa22feeb6
max
  Wed Apr 1 07:30:30 2026 -0700
fixing up regfunc docs and tdb

diff --git src/hg/makeDb/trackDb/human/hg38/regfunc.html src/hg/makeDb/trackDb/human/hg38/regfunc.html
index 94f0ba80ca3..940a9f0bb03 100644
--- src/hg/makeDb/trackDb/human/hg38/regfunc.html
+++ src/hg/makeDb/trackDb/human/hg38/regfunc.html
@@ -1,21 +1,24 @@
 <h2>Description</h2>
 <p>
-Massively Parallel Reporter Assays (MPRAs) are high-throughput experimental methods
-that test thousands of DNA sequences or genetic variants for their effects on gene
-regulation. They work by linking candidate regulatory sequences to reporter genes
-and measuring transcriptional output using sequencing.
+Regulatory functional assays are methods that directly test whether specific
+DNA sequences control gene expression - such as by acting as enhancers,
+promoters, silencers, or other regulatory elements — by measuring their effect
+on transcription in cells. Among these, Massively Parallel Reporter Assays
+(MPRAs) are high-throughput experimental methods that test thousands of DNA
+sequences or genetic variants for their effects on gene
+regulation by measuring transcriptional output using sequencing.
 </p>
 <p>
 This track collection brings together results from two MPRA databases, one for the complete sequence fragments, 
 one for the variants in selected fragments:
 </p>
 
 <ul>
 <li><b><a href="hgTrackUi?g=mprabase">MPRA Base</a></b> &mdash;
 41,275 experimentally tested cis-regulatory elements from 51 MPRA, STARR-seq,
 and related reporter assay experiments, curated in the MPRA Base database
 (<a href="https://pubmed.ncbi.nlm.nih.gov/38045264/" target="_blank">Zhao et al., 2023</a>).
 </li>
 <li><b><a href="hgTrackUi?g=mpraVarDb">MPRAVarDB</a></b> &mdash;
 242,818 variants from 18 MPRA studies, tested for effects on transcriptional
 regulatory activity across over 30 cell lines and 30 human diseases and traits