31b7d4342181171f8b8271e5ed5b5cdaa22feeb6 max Wed Apr 1 07:30:30 2026 -0700 fixing up regfunc docs and tdb diff --git src/hg/makeDb/trackDb/human/hg38/regfunc.html src/hg/makeDb/trackDb/human/hg38/regfunc.html index 94f0ba80ca3..940a9f0bb03 100644 --- src/hg/makeDb/trackDb/human/hg38/regfunc.html +++ src/hg/makeDb/trackDb/human/hg38/regfunc.html @@ -1,21 +1,24 @@ <h2>Description</h2> <p> -Massively Parallel Reporter Assays (MPRAs) are high-throughput experimental methods -that test thousands of DNA sequences or genetic variants for their effects on gene -regulation. They work by linking candidate regulatory sequences to reporter genes -and measuring transcriptional output using sequencing. +Regulatory functional assays are methods that directly test whether specific +DNA sequences control gene expression - such as by acting as enhancers, +promoters, silencers, or other regulatory elements — by measuring their effect +on transcription in cells. Among these, Massively Parallel Reporter Assays +(MPRAs) are high-throughput experimental methods that test thousands of DNA +sequences or genetic variants for their effects on gene +regulation by measuring transcriptional output using sequencing. </p> <p> This track collection brings together results from two MPRA databases, one for the complete sequence fragments, one for the variants in selected fragments: </p> <ul> <li><b><a href="hgTrackUi?g=mprabase">MPRA Base</a></b> — 41,275 experimentally tested cis-regulatory elements from 51 MPRA, STARR-seq, and related reporter assay experiments, curated in the MPRA Base database (<a href="https://pubmed.ncbi.nlm.nih.gov/38045264/" target="_blank">Zhao et al., 2023</a>). </li> <li><b><a href="hgTrackUi?g=mpraVarDb">MPRAVarDB</a></b> — 242,818 variants from 18 MPRA studies, tested for effects on transcriptional regulatory activity across over 30 cell lines and 30 human diseases and traits