ce180274fa3ba3db5c10ecbd9ae2479d4816e972
max
  Tue Mar 10 04:00:45 2026 -0700
Add MPRAVarDB track: 239k MPRA-tested regulatory variants from 18 studies

Convert MPRAVarDB CSV (Wang et al. 2024) to bigBed9+ with liftOver of
hg19 variants to hg38. Color by significance (red=FDR<0.05, orange=p<0.05,
grey=not significant). MouseOver shows ref/alt/cell line/log2FC/p/FDR.
Track added to existing MPRAs superTrack, refs #34284

Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>

diff --git src/hg/makeDb/trackDb/human/hg38/mpra.ra src/hg/makeDb/trackDb/human/hg38/mpra.ra
index 6f7c6679dce..8811a0179cc 100644
--- src/hg/makeDb/trackDb/human/hg38/mpra.ra
+++ src/hg/makeDb/trackDb/human/hg38/mpra.ra
@@ -1,19 +1,30 @@
 track mpra
 shortLabel MPRAs
 longLabel Massively Parallel Reporter Assays
 group phenDis
 type bed 4
 visibility hide
 superTrack on
 
         track mprabase
         shortLabel MPRA-base
         longLabel MPRAs: MPRA-base
         parent mpra on
         bigDataUrl /gbdb/hg38/mpra/mprabase/mprabase.bb
         visibility pack
         type bigBed 4
         dataVersion hg38CustomLift
         priority 1
 
-
+        track mpraVarDb
+        shortLabel MPRAVarDB
+        longLabel MPRAs: MPRAVarDB - MPRA-tested Regulatory Variant Effects - grey is non-significant
+        parent mpra on
+        bigDataUrl /gbdb/hg38/mpra/mpravardb.bb
+        type bigBed 9 +
+        itemRgb on
+        visibility dense
+        mouseOverField _mouseOverLog2FC,_mouseOverPvalue,_mouseOverFdr
+        mouseOver Ref: $ref Alt: $alt Cell: $cellLine log2FC: $_mouseOverLog2FC p: $_mouseOverPvalue FDR: $_mouseOverFdr
+        skipFields _mouseOverLog2FC,_mouseOverPvalue,_mouseOverFdr
+        priority 2