e82a8101c1aa495e0e6c841f83f4d6c980fddf49
max
  Thu Mar 12 07:28:49 2026 -0700
Add STRchive disease-associated STR loci track to strVar supertrack

75 curated disease-associated tandem repeat expansion loci from
STRchive (Hiatt et al. 2025), with pathogenic thresholds, inheritance
modes, and disease annotations. Colored by inheritance mode, refs #36652

Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>

diff --git src/hg/makeDb/trackDb/human/hg38/strVar.html src/hg/makeDb/trackDb/human/hg38/strVar.html
index 5feb265b958..e986d439cad 100644
--- src/hg/makeDb/trackDb/human/hg38/strVar.html
+++ src/hg/makeDb/trackDb/human/hg38/strVar.html
@@ -1,27 +1,31 @@
 <h2>Description</h2>
 <p>
 The <b>Short Tandem Repeat (STR) Variation</b> super track is a collection of tracks
 displaying population-level genetic variation at short tandem repeat (STR) loci across
 the human genome. STRs, also known as microsatellites, are consecutive repetitions of
 1-6 nucleotide motifs. They are among the most polymorphic loci in the genome due to high
 rates of repeat unit insertions and deletions caused primarily by polymerase slippage
 during DNA replication.</p>
 
 <p>
 STR variation has been implicated in a range of human traits and diseases,
 including gene expression regulation, cancer risk, and neurodevelopmental disorders.
-This super track provides genome-wide STR annotations and allele frequency data from
-large-scale population cohorts.</p>
+This super track provides genome-wide STR annotations, allele frequency data from
+large-scale population cohorts, and curated disease-associated STR loci.</p>
 
 <h2>Tracks in this collection</h2>
 <ul>
 <li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=webstr">WebSTR</a></b> &mdash;
 1.7 million STR loci from the EnsembleTR panel with allele frequency data from the
 1000 Genomes Project (3,550 individuals across five continental populations).
 See the <a href="webstr.html">WebSTR track documentation</a> for full details.</li>
+<li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=strchive">STRchive</a></b> &mdash;
+75 disease-associated tandem repeat loci curated from published literature, with
+pathogenic repeat thresholds, inheritance modes, and disease annotations.
+See the <a href="strchive.html">STRchive track documentation</a> for full details.</li>
 </ul>
 
 <h2>Credits</h2>
 <p>
 Thanks to the data providers of the individual tracks listed above.
 See each track's documentation page for specific credits.</p>