e82a8101c1aa495e0e6c841f83f4d6c980fddf49 max Thu Mar 12 07:28:49 2026 -0700 Add STRchive disease-associated STR loci track to strVar supertrack 75 curated disease-associated tandem repeat expansion loci from STRchive (Hiatt et al. 2025), with pathogenic thresholds, inheritance modes, and disease annotations. Colored by inheritance mode, refs #36652 Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com> diff --git src/hg/makeDb/trackDb/human/hg38/strVar.html src/hg/makeDb/trackDb/human/hg38/strVar.html index 5feb265b958..e986d439cad 100644 --- src/hg/makeDb/trackDb/human/hg38/strVar.html +++ src/hg/makeDb/trackDb/human/hg38/strVar.html @@ -1,27 +1,31 @@ <h2>Description</h2> <p> The <b>Short Tandem Repeat (STR) Variation</b> super track is a collection of tracks displaying population-level genetic variation at short tandem repeat (STR) loci across the human genome. STRs, also known as microsatellites, are consecutive repetitions of 1-6 nucleotide motifs. They are among the most polymorphic loci in the genome due to high rates of repeat unit insertions and deletions caused primarily by polymerase slippage during DNA replication.</p> <p> STR variation has been implicated in a range of human traits and diseases, including gene expression regulation, cancer risk, and neurodevelopmental disorders. -This super track provides genome-wide STR annotations and allele frequency data from -large-scale population cohorts.</p> +This super track provides genome-wide STR annotations, allele frequency data from +large-scale population cohorts, and curated disease-associated STR loci.</p> <h2>Tracks in this collection</h2> <ul> <li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=webstr">WebSTR</a></b> — 1.7 million STR loci from the EnsembleTR panel with allele frequency data from the 1000 Genomes Project (3,550 individuals across five continental populations). See the <a href="webstr.html">WebSTR track documentation</a> for full details.</li> +<li><b><a href="/cgi-bin/hgTrackUi?db=hg38&g=strchive">STRchive</a></b> — +75 disease-associated tandem repeat loci curated from published literature, with +pathogenic repeat thresholds, inheritance modes, and disease annotations. +See the <a href="strchive.html">STRchive track documentation</a> for full details.</li> </ul> <h2>Credits</h2> <p> Thanks to the data providers of the individual tracks listed above. See each track's documentation page for specific credits.</p>