fa272dac584b8d450211f426b50c5e9e6de114c8
mspeir
Tue Sep 22 08:40:34 2026 -0700
New FAQ page on regulation and cis-regulatory tracks, refs #24610
Adds FAQ/FAQregulation.html, the page requested in this ticket since 2019:
where to find transcription factor binding site data, and how the various
cis-regulatory tracks relate to each other.
The page is organized around the measured vs predicted distinction, which is
what most of the mailing list questions turn on, and then covers which TFBS
tracks to use, what to do when a factor is in none of them, loading ENCODE
portal data through the portal's own Visualize button, promoters, enhancers,
cCREs, restricting to a cell type, and working outward from a gene. It ends
with a summary table of 16 tracks.
Assembly coverage is given per track and every assembly name is a link to
that track's description page on that assembly, since coverage varies a lot
(mm39 carries only three of these tracks, and TFBS Conserved was never built
for hg38).
Also adds the category to FAQ/index.html and a cross-link from the promoter
sequence question in FAQ/FAQdownloads.html.
Co-Authored-By: Claude Opus 5 (1M context)
You can also use the Genome Browser to obtain sequence for a specific gene. Open the Genome Browser window to display the gene in which you're interested. Click the entry for the gene in the RefSeq or Known Genes track, then click the Genomic Sequence link. Alternatively, you can click the DNA link in the top menu bar of the Genome Browser tracks window to access options for displaying the sequence.
The Stanford Human Promoters track on the UCSC Custom Annotation Tracks page shows promoters for some of the human assemblies.
++If you want annotated promoter regions rather than upstream sequence, see +Which tracks show promoters? in the regulation FAQ.
The conservation score data are stored in a group of tables in the annotation database downloads directory. The naming conventions of the tables vary among releases. In earlier assemblies, table names are of the form chrN_humMusL, chrN_zoom1_humMusL, and or chrN_zoom2500_humMusL. In later releases, the tables are named using specific release numbers, such as chrN_hg16Mm3. The tables within a given set differ by the number of bases/score interval and are used to generate the browser displays at different zooming levels.