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Smaller software changes are not announced here. A summary of the three-weekly release changes can be found here. For the full list of our daily code changes head to our GitHub page. Lastly, see our credits page for acknowledgments of the data we host.
+ + ++We are happy to announce the release of the +Missense Deleteriousness Prediction by Constraint (MPC) track for hg19, +now available in the +gnomAD superTrack. This track shows a score that tries to identify +missense-depleted regions using the patterns of rare missense variation in 125,748 gnomAD v2.1.1 +exomes, compared to a null mutational model. Missense-depleted regions are enriched for ClinVar pathogenic +variants, de novo missense variants in individuals with neurodevelopmental disorders (NDDs), and +complex trait heritability. This track can be used to aid in interpreting missense variants.
++Transcript regions with constraint predictions are colored using the viridis palette, where yellow +indicates the lowest OE values and dark blue-purple indicates the highest.
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++A corresponding MPC version for hg38 is planned for release by the gnomAD team in 2026.
++We would like to thank Kaitlin Samocha for suggesting this track and the +Genome Aggregation Database Consortium (gnomAD) for making the data +available. We would also like to thank Maximilian Haeussler, Luis Nassar, and Gerardo Perez for the +creation and release of this track.
+ + +We are pleased to announce the release 2 of the Varaico Variants track and the addition of a new Varaico Variants (suppl) track for the human assemblies hg38/GRCh38 and hg19/GRCh37. The Varaico tracks are generated using literature mining methods similar to those used for the AVADA resource. With this update, the Varaico Variants track now contains more than 5.5 million variants.
The Varaico Variants (suppl) track shows variants extracted from supplementary data files using