e7e1e5f0e9e4e242f19f4e04856c94574cbec7a7 gperez2 Wed Dec 3 13:26:29 2025 -0800 An edit to the gnomAD MPC newsarch, refs #36531 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 33d35aad9b6..cf5afb2d4fd 100755 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -58,32 +58,32 @@ found <a target=_blank href="https://genecats.gi.ucsc.edu/builds/versions.html">here</a>. For the full list of our daily code changes head to our <a href="https://github.com/ucscGenomeBrowser/kent/commits/master" target=_blank>GitHub page</a>. Lastly, see our <a href="credits.html" target="_blank"> credits page</a> for acknowledgments of the data we host.</p> <!-- ============= 2025 archived news ============= --> <a name="2025"></a> <a name="120325"></a> <h2>Dec. 03, 2025 New gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19</h2> <p> We are happy to announce the release of the <a href="/cgi-bin/hgTrackUi?db=hg19&position=default&g=gnomadMpc" - target="_blank">Missense Deleteriousness Prediction by Constraint (MPC) track</a> for hg19, -now available in the + target="_blank">gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track</a> +for hg19, now available in the <a href="/cgi-bin/hgTrackUi?db=hg19&position=default&g=gnomadSuper" target="_blank">gnomAD superTrack</a>. This track shows a score that tries to identify missense-depleted regions using the patterns of rare missense variation in 125,748 gnomAD v2.1.1 exomes, compared to a null mutational model. Missense-depleted regions are enriched for ClinVar pathogenic variants, de novo missense variants in individuals with neurodevelopmental disorders (NDDs), and complex trait heritability. This track can be used to aid in interpreting missense variants.</p> <p> Transcript regions with constraint predictions are colored using the viridis palette, where yellow indicates the lowest OE values and dark blue-purple indicates the highest.</p> <div class="text-center"> <img src="../../images/newsArchImages/gnomAD_mpc.png" width='80%'></a> </div> <p> A corresponding MPC version for hg38 is planned for release by the gnomAD team in 2026.</p> <p>