a3b068a5c19262b2ad74db394e508fd61c7eb6b0
gperez2
  Sun Aug 23 22:23:09 2026 -0700
Updating gnomadMpc.html's transcript count to the verified 18,245 and updating the tag to beta, refs #37478

diff --git src/hg/makeDb/trackDb/human/hg38/gnomadMpc.html src/hg/makeDb/trackDb/human/hg38/gnomadMpc.html
index 69f6390e06d..373e878e0de 100644
--- src/hg/makeDb/trackDb/human/hg38/gnomadMpc.html
+++ src/hg/makeDb/trackDb/human/hg38/gnomadMpc.html
@@ -1,26 +1,24 @@
 <h2>Description</h2>
 <p>
 This track shows MPC v4.1.1 ("Missense deleteriousness Prediction by
 Constraint"), a machine-learning score that predicts which missense variants
 are likely to be deleterious. It was computed by the Broad Institute gnomAD
 team from the <b>gnomAD v4.1.1</b> release of 730,947 exomes aligned to
 GRCh38/hg38. Scores are provided for every possible single-nucleotide
-missense variant in 17,841 MANE Select or canonical protein-coding
-transcripts that passed gnomAD QC, as well as for an additional 1,534
-transcripts that failed QC (the authors note that scores may be less
-accurate in these 1,534 transcripts).
+missense variant across 18,245 MANE Select or canonical protein-coding
+transcripts.
 </p>
 
 <p>
 Missense variants change a single amino acid in a protein and are a common
 source of variants of uncertain significance (VUS): about 90% of missense
 variants in ClinVar are VUS. MPC predicts which missense variants are likely
 deleterious by combining three lines of evidence: (i) regional missense constraint (how
 depleted the surrounding sub-genic region is of rare missense variation in
 the general population), (ii) the biochemical severity of the specific
 amino-acid substitution and additional protein-structure and homology
 information from PolyPhen-2, and (iii) cross-species conservation (phyloP).
 Higher scores indicate greater predicted deleteriousness.
 </p>
 
 <p>