ca48d17f1e4bc1e975c84fd3bf3cf18d0d59f577 jnavarr5 Tue Aug 18 14:38:25 2026 -0700 Implementing Lou's suggestion from code review, refs #38138 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index e2a0d82b51b..901a4a30d7e 100644 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -56,32 +56,32 @@ <p>Smaller software changes are not announced here. A summary of the three-weekly release changes can be found <a target=_blank href="https://genecats.gi.ucsc.edu/builds/versions.html">here</a>. For the full list of our daily code changes head to our <a href="https://github.com/ucscGenomeBrowser/kent/commits/master" target=_blank>GitHub page</a>. Lastly, see our <a href="credits.html" target="_blank"> credits page</a> for acknowledgments of the data we host.</p> <!-- ============= 2026 archived news ============= --> <a name="2026"></a> <a name="081126"></a> <h2>Aug. 11, 2026 Deleteriousness Predictions: ClinPred for hg19 and hg38</h2> <p> We are pleased to announce the release of the ClinPred pathogenicity score track for -<a href="/cgi-bin/hgTrackUi?db=hg19&g=clinPred" target="_blank">hg19</a> and -<a href="/cgi-bin/hgTrackUi?db=hg38&g=clinPred" target="_blank">hg38</a>. +<a href="/cgi-bin/hgTrackUi?db=hg19&g=clinPred&position=default" target="_blank">hg19</a> and +<a href="/cgi-bin/hgTrackUi?db=hg38&g=clinPred&position=default" target="_blank">hg38</a>. ClinPred is a machine-learning predictor of pathogenicity for nonsynonymous (missense) single-nucleotide variants, combining existing pathogenicity scores with population allele frequency from gnomAD. It was trained on confidently annotated disease-causing and benign variants from ClinVar. Pre-computed scores are provided for all possible human missense variants in the exome. </p> <p> Scores range from 0 to 1, with higher values indicating a greater predicted likelihood that a variant is disease-relevant. The authors recommend a score of ≥ 0.5 as evidence of pathogenicity. As with any pathogenicity prediction score, ClinPred is intended as supporting evidence rather than a stand-alone classifier. </p> <p>