The Matched Annotation from NCBI and EMBL-EBI (MANE) project aims to produce a matched set of high-confidence transcripts that are identically annotated between RefSeq (NCBI) and Ensembl/GENCODE (led by EMBL-EBI). Transcripts for MANE are chosen by a combination of automated and manual methods based on conservation, expression levels, clinical significance, and other factors. Transcripts are matched between the NCBI RefSeq and Ensembl/GENCODE annotations based on the GRCh38 genome assembly, with precise 5' and 3' ends defined by high-throughput sequencing or other available data.
-This track is automatically updated, see the source data version above for the current version -number. MANE include almost all human protein-coding genes and genes of clinical relevance, including genes in the +
+This track is automatically updated, see the source data version above for the current +version number. MANE includes almost all human protein-coding genes and genes of clinical relevance, +including genes in the American College of Medical Genetics and Genomics (ACMG) Secondary Findings list (SF) v3.0. It includes both MANE Select and MANE Plus Clinical transcripts. MANE Plus Clinical items are colored red.
For more information on the different gene tracks, including MANE vs GENCODE or RefSeq, see our Genes FAQ.
The raw data can be explored interactively with the Table Browser, or the Data Integrator. For computational analysis, genome annotations are stored in a bigGenePred file that can be downloaded from the download