45c657735672d97ab4e9cfd15d4dbe4b056b9066 jnavarr5 Tue Jun 17 15:24:32 2025 -0700 Adding a leading 0 to the ranges. Adding a period after et al., Using HTML entity for double quotes, no Redmine. diff --git src/hg/makeDb/trackDb/human/revel.html src/hg/makeDb/trackDb/human/revel.html index 7df62e53547..a9438fd0f23 100644 --- src/hg/makeDb/trackDb/human/revel.html +++ src/hg/makeDb/trackDb/human/revel.html @@ -84,58 +84,58 @@

Track colors

This track is colored according to Table 2 in Pejaver et al. The colors represent the recommended ACMG/AMP score cutoffs. - + - + - +
Range Classification
≥ .644≥ 0.644 Pathogenic_supporting
.643 - .2910.643 - 0.291 Neutral
≤ .290≤ 0.290 Benign_supporting

-More details on these scoring ranges can be found in Bergquist et al Genet Med 2025, Table 2: +More details on these scoring ranges can be found in Bergquist et al. Genet Med 2025, Table 2: Table 2 from Bergquist Genet Med 2025

For hg38, note that the data was converted from the hg19 data using the UCSC liftOver program, by the REVEL authors. This can lead to missing values or duplicated values. When a hg38 position is annotated with two scores due to the lifting, the authors removed all the scores for this position. They did the same when the reference allele has changed from hg19 to hg38. Also, on hg38, the track has -the "lifted" icon to indicate +the "lifted" icon to indicate this. You can double-check if a nucleotide position is possibly affected by the lifting procedure by activating the track -"Hg19 Mapping" under "Mapping and Sequencing". +"Hg19 Mapping" under "Mapping and Sequencing".

Data access

REVEL scores are available at the REVEL website. The site provides precomputed REVEL scores for all possible human missense variants to facilitate the identification of pathogenic variants among the large number of rare variants discovered in sequencing studies.

The REVEL data on the UCSC Genome Browser can be explored interactively with the