The above session helps illustrate the display of how one gene can have different transcripts with different stop codons, displayed in red in the browser. Note that the three transcripts that terminate near the right side of the screen are in a different frame from the transcript that terminates near the left side. The three potential reading frames through the region can be seen at the top of the graphic. Only one of the three is free of stop codons throughout this range.
A premature stop codon was found in the hg18 reference genome and in about half of people of
European descent. The UCSC Genes track was forced to skip the codon to indicate a full-length coding
region for this gene. The SNP indicated by the G nucleotide in many of the mRNA alignments shows
that in many samples from Genbank, the T > G transversion encodes a glutamic acid in the protein,
reading through the premature stop predicted by the reference assembly.
