Description

< potPathoIndel |

This track shows genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous < potPathoIndel | deadly coronavirus outbreaks, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), < potPathoIndel | from less pathogenic coronaviruses. These features include:

< potPathoIndel |

< potPathoIndel | Enhancement of the nuclear localization signals in the nucleocapsid protein
Inserts in the spike glycoprotein that appear to be associated with the high case fatality rate < potPathoIndel | of these coronaviruses
< potPathoIndel | Inserts in the spike glycoprotein that appear to be associated with the host switch from animals to humans < potPathoIndel |

< potPathoIndel | < potPathoIndel |

Methods

< potPathoIndel |

< potPathoIndel | We searched for specific regions, within an alignment of 944 human coronaviruses, that contributed the < potPathoIndel | most to the separation between coronaviruses with a high case fatality rate and those with a low case fatality < potPathoIndel | rate, using a combination of comparative genomics and machine learning techniques. For the zoonotic insertions, < potPathoIndel | we scanned an alignment of human and nonhuman coronaviruses to find regions in which over 50% of the strains in < potPathoIndel | the alignment differed from the human strain, and for which the differing strains were explicitly the most distant < potPathoIndel | from human. We identified only one such location, across all three high case fatality rate virus groups. < potPathoIndel |

< potPathoIndel | < potPathoIndel |

References

< potPathoIndel |

Ayal B. Gussow*, Noam Auslander*, Guilhem Faure, Yuri I. Wolf, Feng Zhang, Eugene V. Koonin. < potPathoIndel | < potPathoIndel | Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses. < potPathoIndel | < potPathoIndel | Proceedings of the National Academy of Sciences Jun 2020, 117 (26) 15193-15199; DOI: 10.1073/pnas.2008176117.

--- > potPathoIndel |

Description

> potPathoIndel |

This track shows genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous > potPathoIndel | deadly coronavirus outbreaks, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), > potPathoIndel | from less pathogenic coronaviruses. These features include:

> potPathoIndel |

> potPathoIndel | Enhancement of the nuclear localization signals in the nucleocapsid protein
Inserts in the spike glycoprotein that appear to be associated with the high case fatality rate > potPathoIndel | of these coronaviruses
> potPathoIndel | Inserts in the spike glycoprotein that appear to be associated with the host switch from animals to humans > potPathoIndel |

> potPathoIndel | > potPathoIndel |

Methods

> potPathoIndel |

> potPathoIndel | We searched for specific regions, within an alignment of 944 human coronaviruses, that contributed the > potPathoIndel | most to the separation between coronaviruses with a high case fatality rate and those with a low case fatality > potPathoIndel | rate, using a combination of comparative genomics and machine learning techniques. For the zoonotic insertions, > potPathoIndel | we scanned an alignment of human and nonhuman coronaviruses to find regions in which over 50% of the strains in > potPathoIndel | the alignment differed from the human strain, and for which the differing strains were explicitly the most distant > potPathoIndel | from human. We identified only one such location, across all three high case fatality rate virus groups. > potPathoIndel |

> potPathoIndel | > potPathoIndel |

References

> potPathoIndel |

Ayal B. Gussow*, Noam Auslander*, Guilhem Faure, Yuri I. Wolf, Feng Zhang, Eugene V. Koonin. > potPathoIndel | > potPathoIndel | Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses. > potPathoIndel | > potPathoIndel | Proceedings of the National Academy of Sciences Jun 2020, 117 (26) 15193-15199; DOI: 10.1073/pnas.2008176117.